18.10.2023

WEBINAR: How HPLC-CAD Analysis Can Allow You to See Hidden Extractable Oligomers


Date:  Wednesday, October 18, 2023
Time:  2:00 PM Central European Summer Time
Duration:   1 hour
More information: here

Join for an informative webinar where we'll unveil our innovative in-house method for studying Extractables and Leachables (E&L) substances in common medical and pharmaceutical-grade plastics. We'll dive into the analysis of nylon, polyurethane, and PVC (epoxidized soybean oil) oligomers, showcasing our approach that leverages multiple advanced detectors to analyze a wide range of analytes with diverse chemical properties.

Our method incorporates an ingenious inverse gradient technique, fine-tuned with an in-line mixer and optimized gradient delay times. We'll demonstrate the application of a previously published calculation to determine analyte behavior, classifying them as non-volatiles or semi-volatiles using CAD (Charged Aerosol Detection).

By attending, you'll discover how our approach minimizes inter-analyte response factor variation, enhancing quantitative accuracy and reducing uncertainty in setting analytical evaluation thresholds. Ultimately, our method is designed to meet crucial requirements in E&L studies, ensuring efficient and cost-effective protection against potentially harmful substances. Don't miss this opportunity to stay at the forefront of E&L research.

Speakers: 

  • Katherine Lovejoy, Product Applications Specialist, Thermo Fisher Scientific
  • Chris Tuczemskyi, Moderator, Product Marketing Manager, Thermo Fisher Scientific

Learning points:

  • determine which analytes behave as non-volatiles with CAD and can therefore be accurately quantified using surrogate standards
  • improve quantification accuracy and reduce response factor variation using an inverse gradient
  • use an in-line mixer to combine the analytical and inverse gradients and improve response uniformity

Who should attend:

  • Laboratory managers and directors
  • Technology leaders 
  • Principal scientists 
  • Laboratory analyst 

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Looking forward to meeting you!

Pragolab & Thermo Fisher Scientific